P92 Cutaneous manifestations of myelodysplastic syndrome: a systematic review

Abstract A variety of associations between cutaneous manifestations and myelodysplastic syndrome (MDS) have been described, but the frequency is unknown. The presence may therapeutic prognostic significance, as thereof has reported to be associated with poor prognosis or acute myeloid leukaemia (AML) progression, precede diagnosis MDS [Farah C, Bulai Livideanu Jegu J et al. Prevalence value in patients syndrome. Eur Acad Dermatol Venereol 2010; 24:1171–5; Ghoufi L, Ortonne N, Ingen-Housz-Oro S Histiocytoid Sweet more frequently syndromes than classical neutrophilic variant: a comparative series 62 patients. Medicine (Baltimore) 2016; 95:e3033]. We aimed determine types prevalence MDS, treatment options specific subtypes. PubMed, MEDLINE Embase were searched from inception up 26 January 2023 for studies reporting adults aged ≥ 18 years, per World Health Organization classification. Case reports case included. review was registered PROSPERO (CRD42021293140). In total, 92 included (case n = 71, 21), consisting 140 [98 male, mean age 61.0 (SD 15.4)]. identified six common manifestations: neutrophilic, e.g. pyoderma gangrenosum (n 66); vasculitis, leucocytoclastic vasculitis Behçet disease 21); granulomatous, granuloma annulare interstitial granulomatous dermatitis 8); connective tissue (CTD), dermatomyositis 7); panniculitis 4); immunobullous 2); other 30). (81.8%) (18.2%) commonest presentations dermatosis. Cutaneous features either occurred at time 24.7%, preceded 36.1% (mean 17 months; range 0.5–216), after 39.2% 20.6 msonths; 1–132). Prognosis (40.2% death) 34.1% progressing (AML), 50% which had Death 38.5% dermatoses (median onset manifestation: 12 months), (7.5 62.5% (15.5 14.3% CTD (7 none panniculitis. Granulomatous skin lesions poorest prognosis, 60% progressed AML. This systematic highlights Of note, we found that majority cases AML overall; however, highest proportion speculate these confer an increase risk transformation, compared changes.